Abstract
A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect, the red flour beetle Tribolium castaneum. This screen marks the beginning of a non-biased, 'forward genetics' approach to the study of genetic mechanisms operating in Tribolium.See research article http://biomedcentral.com/1741-7007/7/73
Highlights
There has been a pressing need to establish reliable and efficient tools for genetic manipulation in arthropod species that often possess larger genomes than Drosophila, or exhibit longer and less amenable life histories
In a paper published in BMC Biology, Trauner et al [1] report another significant advance: the first large-scale insertional mutagenesis screen in a nondrosophilid arthropod, the red flour beetle Tribolium castaneum
Chemical and/or gamma-irradiation mutagenesis screens selecting for specific classes of mutant phenotype have been carried out before in Tribolium [2,3], as well as in the parasitic wasp Nasonia vitripennis [4]
Summary
There has been a pressing need to establish reliable and efficient tools for genetic manipulation in arthropod species that often possess larger genomes than Drosophila, or exhibit longer and less amenable life histories. In a paper published in BMC Biology, Trauner et al [1] report another significant advance: the first large-scale insertional mutagenesis screen in a nondrosophilid arthropod, the red flour beetle Tribolium castaneum.
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