Abstract
The purpose of this investigation was to formulate, optimize and evaluate sublingual lm for the treatment of schizophrenia and bi polar disorder. Sublingual lms were prepared by solvent casting method. Present investigation 2 were formulated by using HPMC E15 (X ) as polymer and Polyethylene glycol (X ) as plasticizer were chosen as independent variables in 3 full 1 2 factorial design while Tensile strength (TS), Disintegration time (DT) and % Cumulative drug release at 10 min. (% CDR) were taken as dependent variables. The various physical parameters were evaluated for sublingual lms such as thickness, tensile strength, folding endurance, disintegration time, surface pH and % CDR. From the experimental study, it was concluded that the optimized batch ZSF showed 98.4 %, the 4 highest release of the drug. Stability study was performed by taking an optimized formulation and it was observed stable. The sublingual lms 2 showed acceptable results in all studies. 3 full factorial design was successfully applied during preparation, optimization and evaluation of sublingual lms of Ziprasidone. The present investigation showed quick disintegration and fast release of the drug for the treatment of schizophrenia and bi polar disorder.
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