Abstract
Human helminthic infections are prevalent and have serious world health consequences. Praziquantel is frequently recommended anthelmintic therapy provided in tablet form for the oral treatment of schistosome infections. The goal of this study is to create and analyze a patient-friendly flavor masked anthelmintics chewable tablet of Praziquantel using Eudragit® EPO using a "granules coating technology" using a Fluid Bed Processor GPCG 1.1. (Top Spray). This strategy is better as compared to coating of Praziquantel granules with Eudragit EPO in Rapid Mixer Granulator. Due to its limited water solubility, the formulation disintegrates and dissolves slowly at high pH. Drug release was >98% in 60 min. The key excipient in chewable tablets incorporate flavor enhancing agent and sweetening agent. By using wet granulation process the tablet are prepared. Chewable tablets are evaluated by chemical and physical evaluation methods. Physical methods and chemical method include appearance, hardness, friability, disintegration, dissolution, drug content, dosage uniformity, accelerated stability studies, and sensory evaluation.
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