Abstract
The demand for fast dissolving tablets has been growing during the last decade, especially for elderly and children who have swallowing difficulties. In the present work, fast dissolving tablets of metoprolol tartrate, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as superdisintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including weight variation, hardness, friability, in vitro dispersion time, drug-polymer interaction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR and DSC studies. The tablets prepared by the direct compression method had a weight variation in the range of 145 mg to 152 mg, which is below ± 7.5%, a hardness of 3.6 kg/cm² to 4.5 kg/cm², percentage friability of 0.46% to 0.73%, in vitro dispersion time of 18 s to 125 s, drug content uniformity of between 98.12% and 100.03%, a water absorption ratio of 67% to 87%, wetting time of 32 sec. to 64 sec., and an in vitro drug release of 53.92% - 98.82% within 15 min. The IR spectral analysis and DSC study showed no drug interaction with formulation additives of the tablet, and the formulations indicated no significant changes in hardness, friability, drug content or in vitro drug release. Fast dissolving tablets of metoprolol tartrate have enhanced dissolution and will lead to improved bioavailability and more effective therapy.
Highlights
People, children and patients sometimes have difficulties swallowing tablets or hard gelatin capsules
On the basis of requests from patients to enhance their quality of life (QOL), new types of fast dissolving tablets (FDTs) have been developed and released globally by many pharmaceutical companies (Okuda et al, 2011)
Fast dissolving tablets of metoprolol tartrate were prepared by direct compression
Summary
Children and patients sometimes have difficulties swallowing tablets or hard gelatin capsules. On the basis of requests from patients to enhance their quality of life (QOL), new types of FDTs have been developed and released globally by many pharmaceutical companies (Okuda et al, 2011) These tablets display a fast and spontaneous de-aggregation in the mouth, soon after coming into contact with saliva, dissolving the active ingredient and allowing absorption through all possible membranes it comes into contact with during deglutition (Puttewar et al, 2010). Oral administration of bitter active substances through FDT formulations should provide an improved degree of palatability and increased patient compliance with dissolving/disintegrating tablets that include sweeteners and flavors. These additives were not a sufficient means for complete taste-masking. Several approaches have been reported which involve complexation, freezedrying, microencapsulation, fluidized-bed coating and supercritical fluids for taste-masking purposes (Gryczkc et al, 2011)
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