Abstract
Objective: The main objective of the present work was to prepare and evaluate transdermal films and creams of celecoxib inclusions which are nonsteroidal anti-inflammatory drug to treat psoriatic arthritis.
 Methods: Celecoxib inclusions were prepared using β-cyclodextrin to increase the solubility. These inclusions were incorporated in transdermal films. Hydroxy Propyl Methyl Cellulose (HPMC), dibutyl phthalate, propylene glycol, and glycerin were used to prepare the film. Fourier transform infrared and differential scanning calorimetry studies were carried out for pure celecoxib and inclusions. Morphological properties, weight variation, surface pH, percentage elongation, folding endurance, in vitro disintegration, and in vitro diffusion studies were carried out for films.
 Results: All the results obtained were within the limits and confirmed the prolonged drug release and increased solubility of celecoxib inclusions.
 Conclusion: From the results obtained, increase in solubility of celecoxib drug was confirmed by forming inclusions using β-CD as polymer.
Highlights
MethodsCelecoxib inclusions were prepared using β-cyclodextrin to increase the solubility
Psoriatic arthritis (PsA) is a chronic, systemic, and inflammatory disease that affects peripheral joints, connective tissues, and axial skeleton and is associated with psoriasis of skin and nails [1,2]
The mechanism of action of celecoxib is conversion of arachidonate to the PGs which is important in homeostatic function; COX-2 is present in immune cells, blood vessel endothelial cells, and synovial fibroblasts
Summary
Celecoxib inclusions were prepared using β-cyclodextrin to increase the solubility. These inclusions were incorporated in transdermal films. Hydroxy Propyl Methyl Cellulose (HPMC), dibutyl phthalate, propylene glycol, and glycerin were used to prepare the film. Fourier transform infrared and differential scanning calorimetry studies were carried out for pure celecoxib and inclusions. Morphological properties, weight variation, surface pH, percentage elongation, folding endurance, in vitro disintegration, and in vitro diffusion studies were carried out for films
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