Abstract
Topical gel formulations of Aceclofenac were prepared using these polymers such as Carbopolâ€934, Carbopolâ€941, HPMC, Poloxamer 407 in different concentration for the treatment of rheumatoid arthritis. The gels were evaluated for various parameters such as homogeneity, grittiness, skin irritancy, extrudability, in vitro drug release, viscosity(Brooke field viscometer), pH, drug content, stability studies. The in vitro release rate of gel was evaluated using Franz diffusion cell containing cellophane membrane with phosphate buffer pH 7.4 as the receptor medium. The release rate of the gel was found to obey Higuchi model. The percentage of drug release follow following order Poloxamer-407> HPMC> Carbopol-940>Carbopol-934. Keywords: Aceclofenac, carbopol, poloxamer hydroxyl propyl methyl cellulose, anti inflammatory activity.
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