Abstract
The objective of this work was to prepare and evaluate oral sustained release matrix tablet of Nateglinide and to study the effect of proportion of wax and addition of release liner on in-vitro release of drug.The prepared tablets were evaluated for pre and post compression parameters. Stability study of the promising formulation was also performed. The matrix tablets were prepared by Direct compression, Co-processed & melt granulation, method using wax in concentration 25%, 35% & 45% and evaluated for on in-vitro drug release using Compritol & Precirol. No interactions were found between drug and excipients. Formulation containing 25% Precirol F13 shows releases up to 12 hours. Tablets with release characteristics offers critical advantages such as site specificity with improved absorption and efficacy etc. Keywords: Nateglinide, Sustained release, Compritol 888, Precirol ATO 5, Melt Granulation, Direct compression,
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