Formulation and Evaluation of Paracetamol Tablet to Assess Binding Property of Limonia acidissima Pectin

Abstract

Plants acts as a major source of medicines and are used to formulate various pharmaceutical preparations. Apart from this they act as excellent pharmaceutical aids and excipients.Limonia acidissima is nutritious, easily available, cheap but underutilized fruit. The aim of present research is to isolate the pectin from dried fruit pulp of Limonia acidissima and to assess its binding property. Pectin was extracted by boiling dried fruit pulp powder with water for 7 hrs at pH 3.2 adjusted with citric acid and using ethanol as precipitating agent. Binding property of pectin was assessed using paracetamol as a model drug. Paracetamol granules were prepared by wet granulationmethod. Granules were prepared using starch as disintegrant, calcium carbonate as filler, talc as glidant, Magnesiumstearate as lubricant and varying concentration of pectin as binder and were compressed into respective tablets.A reference batch of starch as binder was prepared to carry out the comparative study and to assess the binding property of pectin. Total four batches of formulation were prepared using different concentrations of pectin. For each formulation pre compression and post compression studies were performed and compared to range asper pharmacopoeias. Tablets were evaluated based on Weight uniformity, Tablet Hardness, Friability, Disintegration and In vitro drug release. The results obtained for all pre-compression and post compression parameters were found within acceptable range of pharmacopoeias. Limonia acidissima pectin can act as excellent binder in dosage forms. In vitro dissolution studies were revealed that batch F3 showed 99.64 % of drug release. In pharmaceutical dosage form like tablet, Limonia acidissima pectin acts as an excellent binder since it is of natural origin and Limonia acidissima fruits were available easily at very low costand proved to be better alternative for synthetic binder.