ABSTRACTObjective: Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. The main aim of this study was tooptimize and evaluate the floating tablets of domperidone that prolongs the gastric residence time using Hibiscus rosa-sinensis mucilage.Methods: The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcelluloseK100 M, carbopol 934P and H. rosa-sinensis mucilage. The effervescent components sodium bicarbonate is used for the generation of CO2 gas. Theprepared tablets were evaluated for physicochemical parameters and found to be within range, viz., hardness, swelling index, floating capacity,thickness, and weight variation. Further, tablets were evaluated for in vitro release characteristics. The concentration of H. rosa-sinensis mucilage witha gas-generating agent was optimized to get the sustained release of domperidone.Result: The % cumulative drug release of all formulation from F1 to F6 was within the range of 81.37% to 98.62% for 18 hrs. The release kinetics ofall the dosage forms was calculated using zero order, first order, Higuchi, and Korsmeyer–Peppas. It concludes that the release followed zero orderrelease, whereas the correlation coefficient (r2 value) was higher for zero order release. The release mechanism follows Higuchi model, Korsmeyer-Peppas model, and non-Fickian diffusion.Conclusion: As a result of this study, it may be concluded that the floating tablets using H. rosa-sinensis mucilage in optimized concentrations canbe used to increase the gastric retention time of the dissolution fluid in the stomach to deliver the drug in a sustained manner. Furthermore, from1 month stability data shows no significant change compared to initial result.Keywords: Floating drug delivery, Hibiscus rosa-sinensis mucilage, Domperidone.

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