Abstract
Objective: The aim of the study was to prepare and evaluate buccal-adhesive tablets of buspirone hydrochloric acid (HCl) that avoids gastric degradation and first-pass metabolism, thereby increasing the drug bioavailability and onset of action. Buspirone HCl belongs to a class anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds.
 Methods: In the present work, different ratios of Gantrez MS 955 along with Carbopol 934 were studied to give bioadhesive strength. A 32 full factorial design was applied to investigate the combined effect of Gantrez MS 955 concentration (X1) and Carbopol 934 concentration (X2).
 Results: Results of the multiple regression analysis revealed that the independent variables significantly affected the dependent variables (bioadhesive strength [Y1], Q2 [Y2], Q3 [Y3], Q4 [Y4]). On the basis of multiple linear regression analysis and contour plot evaluation, it was found that the combination of two polymers possessed excellent mucoadhesive properties allowing ease of application and removal of the tablets from the buccal mucosa.
 Conclusion: The formulation batch A9 fulfilled all the criteria set from the desirability search. From the in vitro diffusion study, flux was calculated for the optimized batch. A study of the effect of tablet diameter and the environmental factors on the bioadhesion of the tablet was done. To study the environmental factor on bioadhesion, prehydration time and contact time were considered. Results found that increase in prehydration time decrease in bioadhesive strength and increase in contact time increased bioadhesive strength. Thus, a stable buccoadhesive formulation optimized for formulation ingredients and process parameters was prepared successfully.
Highlights
Buccal mucosa is an attractive route for systemic delivery of drugs as it is relatively permeable with a rich blood supply
Buccal delivery for the transmucosal absorption of drugs into the systemic circulation offers a number of advantages over oral delivery, especially for those drugs that have poor oral bioavailability and/or those drugs that suffer from extensive first-pass metabolism in the liver
Buspirone hydrochloric acid (HCl) is an anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds
Summary
Buccal mucosa is an attractive route for systemic delivery of drugs as it is relatively permeable with a rich blood supply. Buspirone hydrochloric acid (HCl) is an anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. It is used in the treatment of generalized anxiety, where it has advantages over other anti-anxiety drugs because it does not cause sedation (drowsiness) and does not cause tolerance or physical dependence. Carbopol 934 (carbomers) is polyacrylic acid and Gantrez MS 955 is polyacrylic acid derivative, having both anion and cation [9,10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Asian Journal of Pharmaceutical and Clinical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
