Abstract
Piroxicam (PIR) is a nonsteroidal anti-inflammatory drug of oxicam category, used in gout, arthritis, as well as other inflammatory conditions (topically and orally). PIR is practically insoluble in water, therefore the aim is prepare and evaluate piroxicam as liquid self-nanoemulsifying drug delivery system to enhance its dispersibility and stability. The Dispersibilty and Stability study have been conducted in Oil, Surfactant and Co-surfactant for choosing the best materials to dissolve piroxicam. The pseudo ternary phase diagrams have been set at 1:1, 2:1, 3:1 as well as 4:1 ratio of surfactants and co-surfactants, also there are 4 formulations were prepared by using various concentrations of transcutol HP, cremophore EL and triacetin oil. All the constructed prepared formulas have been assessed for in vitro drug dissolution, thermodynamic stability, polydispersity index, robustness to dilution, particle size distribution, drug content, and the dispersibility and emulsification time.From the presented research concluded that the self-nanoemulsifying drug delivery system is the convenient method for improving Dispersibilty and Stability of piroxicam.
 Keywords: Pseudo-ternary phase diagram, Dissolution rate, SNEDDS, Piroxicam.
Highlights
There is poor water solubility in about fifty percent of new drug compounds, the oral delivery of this type of drugs has indicated the presence of low bioavailability
As can be seen in the (Table 4), surfactant cremophore EL and co-surfactant transcutol HP were shown a highest solubility for PIR and they were chosen for the study
Pseudo- ternary phase diagram construction Pseudo-ternary phase diagrams have been developed for identifying self- emulsifying regions and SNEDDS formulations, pseudo-ternary phase diagram plot for various Smix ratios
Summary
There is poor water solubility in about fifty percent of new drug compounds, the oral delivery of this type of drugs has indicated the presence of low bioavailability. There are alot of formulation plans like using solid dispersions, cyclodextrin inclusion complex, micronization, lipids, surfactants, permeation enhancers, salt formulation and nano-particles which are currently applied for overcoming such challenges [1]. The physically stable formulations like emulsion preconcentrates, emulsions and the lipid solutions are widely applied to encapsulate the poorly soluble drugs [3]. The (SNEDDS) is defined as anhydrous forms thermodynamically stable and transparent or translucent non-ionized dispersion or nanoemulsion pre-concentrates. Such systems are considered as anhydrous isotropic mix of co-surfactant, surfactant, oil and the drug, that spontaneously form O/W nanoemulsions when introduced into aqueous phase under conditions of gentle agitation, usually with globule size less than 200 nm
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