Abstract
The present study involves preparation and evaluation of floating microballoons of norfloxacin for improving the bioavailability by prolongation of gastric residence time. norfloxacin, a sparingly water soluble drug, was selected and microballoons were prepared by emulsion solvent diffusion method using Eudragit L-100 and Eudragit RS-100 in ethyl alcohol and dichloromethane organic solvent system. The formation of a sphere and hollow within the sphere was confirmed through SEM studies. The percentage of drug entrapment and recovery was found to be 75- 80%. The micromeritic properties indicated better flowability and packability of the spheres. The Buoyancy test showed good floatability of norfloxacin microballoons in the simulated gastric fluid for more than 12 h. In vitro dissolution profile showed prolonged release of drug from the formulations. Thus microballoons of norfloxacin with acrylic polymers prepared by emulsion solvent diffusion proves to be an ideal novel floating dosage form that is adaptable to any intragastric condition for controlled drug delivery and enhanced bioavailability.Keywords: norfloxacin, hollow microspheres, acrylic polymers, evaluation
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
