Formulation and Characterization of Liposomes containing Clindamycin and Green tea for Anti Acne

Abstract

Novel drug delivery carriers such as liposomes are very versatile to suit the delivery of various drug molecules. Clindamycin is generally considered the most effective antibiotic in treatment of acne. Topical clindamycin are used less often due to lower efficacy or increased side effects. Thus, liposomes have been selected for the present work assuming that incorporation of Clindamycin into liposomes may reduce the side effects associated with it. To overcome the potential risk of adverse effects and antibiotic resistance from prescription medications, traditional herbal medicines have been extensively studied as alternative treatments for many diseases. Green tea is one of the best herbal remedies known to treat acne because of its antibacterial properties. Liposomes with drug were prepared using lipid film hydration method and the optimum ratios of the components were determined. The liposomes were characterized for their vesicle size, shape, encapsulation efficiency, drug content and in-vitro drug release study. Highest encapsulation efficiency (69.5% and 66.2%) and in-vitro drug release (82.5% and 82.2%) was achieved with formulation F1 and F6 respectively, containing lipid: cholesterol in the ratio of 1: 1. Liposomal formulations have been incorporated into carbopol gel base and comparison of that has been made with non liposomal marketed gel. The non liposomal marketed gel showed higher release (90.5%) than liposomal gel of clindamycin (77.5%) and green tea (74.8%) within 24 hours. MIC of formulated liposomal green tea was comparable with the marketed non liposomal gel. Clindamycin found to be more superior against Micrococcus luteus than green tea.