Abstract
The core objective of the present study was to formulate and characterize Gliclazide nanosuspension by using different polymers to improve the solubility and bioavailability of a drug. The formulation of Gliclazide Nanosuspension was done by the Nano precipitation method. The formulations were prepared by different polymers and surfactants. The formed nanosuspension was clear and no sedimentation on shaking. The Gliclazide formulation showed maximum solubility in HPMC. The preformulation parameters were evaluated like solubility, identification of sample by UV spectroscopy, FTIR studies. The viscosity of the dispersion medium was in F5 0.89m Pa-s, the zeta potential value was found to be-20.5mv. The SEM studies showed that the nanoparticles had a smooth surface. All the fabricated Gliclazide Nanosuspension were subjected to In vitro drug release, in this F5 which showed the highest % of drug release. The optimized formulation (F5) was compared with the marketed sample which has the same release pattern. The release kinetics confirmed that the optimized formulation followed zero-order kinetics. From this study, it has been concluded that the modified liquid dosage form complies the patient compliance and it is suitable for dose titration therapy in diabetes treatment.
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