Abstract
Katuk (Sauropus androgynus (L.) Merr.) is a plant that has secondary metabolic compounds with various potentials and contains several chemical compounds, including papaverine alkaloids, proteins, fats, vitamins, minerals, saponins, flavonoids and tannins. Katuk leaves can work as antioxidants because they contain phenolic compounds, namely flavonoids. The potential of katuk leaves is also supported by research on pharmacological activities as antibacterial, antihypertensive, antihyperlipidemic, anti-infective, anti-inflammatory, antianemic and increasing milk production. The purpose of this study was to determine whether katuk leaves can be formulated in the form of an ointment. Ointment is defined as a semi-solid preparation that is easily applied and used as an external drug. Ointment is also one of the dosage forms with a semisolid consistency that is oily and generally does not contain water and contains the active ingredient dissolved or dispersed in a vehicle. This study used 4 treatments with various concentrations, namely FO: control formulation of ointment base, FI: formulation of katuk leaf extract ointment preparation with 10% concentration, FII: formulation of katuk leaf extract ointment preparation with 15% concentration, FIII: formulation of katuk leaf extract ointment preparation with a concentration of 20%. Evaluation of the ointment using organoleptic tests, homogeneity, pH, spreadability, stability and irritation. The results of the evaluation carried out on the ointment preparation were stable and did not irritate the skin.
Highlights
a plant that has secondary metabolic compounds with various potentials
Katuk leaves can work as antioxidants because they contain phenolic compounds
The potential of katuk leaves is also supported by research on pharmacological activities
Summary
Indonesia merupakan salah satu negara yang banyak menghasilkan obat - obatan tradisional, salah satunya adalah tanaman katuk. Tanaman katuk (Sauropus androgynus (L.)Merr.) adalah salah satu tanaman yang memiliki senyawa metabolisme sekunder dengan berbagai potensi dan mengandung beberapa senyawa kimia, antara lain alkaloid papaverin, protein, lemak, vitamin, mineral, saponin, flavonoid dan tanin. Ekstrak daun katuk mengandung senyawa flavonoida dengan nilai IC50 sebesar 80,81, dan termasuk dalam antioksidan yang sangat kuat (Zuhra et al.,2018). Daun katuk sering digunakan dalam bentuk ekstrak sebagai antibakteri, tetapi dirasakan kurang efektif dan efisien. Salah satu sediaan farmasi yang mudah kita gunakan adalah dalam bentuk sediaan salep, karena sediaan salep jika digunakan dengan konsisten sangat cocok untuk terapi penyakit seperti bakteri dan luka. Kandungan kimia dalam daun katuk berkhasiat untuk melindungi struktur sel, meningkatkan efektivitas vitamin C, anti inflamasi, mencegah keropos tulang, dan sebagai antibiotik alami. Fungsi lainnya yaitu berperan langsung sebagai antibiotik dengan mengganggu fungsi mikroorganisme seperti bakteri atau virus dan juga dapat meningkatkan imunitas tubuh (Middleton et al, 2000)
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