Abstract
Background: Among inhaled bronchodilators, formoterol is authorized to have rapid-onset bronchodilatory effect as well as its lastingness. In methacholine bronchial provocation test, salbutamol is frequently used for the reverse medication. We compared to the rapidity of bronchodilatory effects between salbutamol in MDl (metered dose inhaler) applied via spacer and formoterol in Turbuhaler<sup>Ⓡ</sup>.Methods: A randomized and open-Iabeled study. Subjects were randomized to inhale salbutamol 400ug in MDI via spacer, formoterol 9㎍ in Turbuhaler<sup>Ⓡ</sup> or placebo in Turbuhafer<sup>Ⓡ</sup>, when each forced expiratory volume in 1 second falls more than 20% from baseline in bronchial provocation with methacholine. To evaluate rapidity of bronchodilatory effects, recovery times were compared.Results: The recovery times were 5.28±3.70 min in salbutamol group, 5.78±4.16 min in formoterol group, with no statistical significance (p=0.661). However, in placebo group, significant delay was observed (16.88±5.30 min. p<0.01).Conclusions: Formoterol in Turbuhaler could be used as rapid-acting bronchodilatory effect as salbutamol in MDI via spacer after bronchial provocation test.
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