Abstract
This paper investigated the influence of reaction conditions on particle morphology. X-ray powder diffraction (XRD), particle size distribution (PSD), and scanning electron microscopy (SEM) were used to characterize the morphology of barium sulfate. The barium sulfate microspheres were synthesized with BaCl2, Na2SO4, and ethylenediaminetetraacetic acid disodium (EDTA·2Na). The reflectivity of the synthesized barium sulfate microspheres was greater than 99% in the range of 400–700 nm, which was characterized by a reflectance spectrometer. The morphology of the barium sulfate particles and their cross-section were observed by SEM. The prepared microspheres were applied to high-density lipoprotein dry tablets due to their high reflectivity, and the results showed that the prepared tablets had high sensitivity and good repeatability.
Highlights
With excellent physicochemical characteristics, e.g., non-toxicity, acid and alkali resistance, high reflectivity, and high whiteness, barium sulfate (BaSO4 ) has been widely used in pigment filling, in ceramics, as a catalyst carrier [1], an adsorbent [2], a medical contrast agent [3], an additive in polymersand [4,5], and in other fields
The reason for this phenomenon was that the ethylenediaminetetraacetic acid (EDTA) complexing agent controlled the over-saturation of Ba2+ in the solution to achieve homogeneous nucleation, so as to synthesize barium sulfate with a uniform particle size
This paper demonstrated that barium sulfate microspheres synthesized by the EDTA.2Na complex had a higher reflectivity compared with that of commercial barium sulfate, which can reduce the error caused by diffuse reflection during measurement
Summary
E.g., non-toxicity, acid and alkali resistance, high reflectivity, and high whiteness, barium sulfate (BaSO4 ) has been widely used in pigment filling, in ceramics, as a catalyst carrier [1], an adsorbent [2], a medical contrast agent [3], an additive in polymersand [4,5], and in other fields. The homogeneous particle size of BaSO4 microspheres has the advantage of high light reflectivity [9], and the accumulated voids can effectively and uniformly disperse a serum and achieve filtration separation [10,11]. BaSO4 microspheres can be used as a filtration-diffusion-reflection multifunctional layer for medical dry diagnostic reagents. This subject is presently one of the research hotspots and it is one of the key technologies being used to prepare the uniform particle size of micron-sized BaSO4 in the field of medical dry diagnostics
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