Abstract
Administration of very high doses of dichlorphenamide, a carbonic anhydrase inhibitor, in the diet of rats during pregnancy is associated with the production, in some of the offspring, of a deformity consisting of a postaxial defect of the right forelimb. This is not associated with any other demonstrable anatomical abnormalities. This deformity appears to be the same as that caused by acetazolamide, a compound of quite different chemical structure which is also a potent carbonic anhydrase inhibitor.
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