Abstract
Objective To investigate the correlation between the hemodynamic characteristics of time intensity curve(TIC) by contrast enhanced ultrasound(CEUS) and the expression of antigen Ki-67 of the 4 different clinic stages (T0 andTis, T1, T2, T3) in ductal carcinoma in order to predict the grade of the expression of antigen Ki-67 and clinic stages. Methods Masses founded in 80 cases proved by pathological test after resection or needle biopsy were divided into 4 groups base on clinic stages: group 1(T0 andTis) , group 2(T1), group 3(T2), and group 4(T3). Some parameters gained after analyzing TIC of CEUS would be used to make a rank correlation analysis with the expression grade of antigen Ki-67 through immunohistochemical diagnosis. A regression equation would be gained from those parameters which had a correlation with the expression grade of antigen Ki-67 (P<0.05). Results Most TIC of ductal carcinomas were possessed of the characteristics of fast in and slow-out. Compared to the other three groups, group 4(T3) had significant differences in arrive time, time to peak, arrive intensity, peak intensity and area under curve. Compared to group 1(T0 andTis), group 4(T3) had significant differences in continuous time and rising curve's slope and group 3(T2) has significant differences in arrive intensity and area under curve. Parameters entered the regression equation through mult-variable linear regression analysis were arrive time, continuous time, peak intensity and rising curve's slope. R square was 0.831 and adjust R square was 0.822. Through the regression equation verification, 5 cases accorded with the clinic stages standard of ductal carcinoma. Conclusions The hemodynamic characteristics of time intensity curve(TIC) by contrast enhanced ultrasound had a good correlation with the expression grade of antigen Ki-67 of the 4 different clinic stages in ductal carcinoma. The regression equation had a good explanatory and degree of fitting, it can be used to predict the expression grade of antigen Ki-67 and indirectly forecasts clinic stages of ductal carcinoma. Key words: Contrast-enhanced ultrasound; Breast neoplasms; Ki-67 antigen
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
