Abstract
Autoimmune polyglandular syndromes (APS 1 and 2 types) are the primary defeat of the autoimmune process of two or more peripheral endocrine glands, usually leading to their functional failure and often combined with variousthe genogenic (Mendelian) nature of inheritance, when the autoimmune process in the endocrine and non-endocrine organs is caused by a mutation of a single AIRE gene (autoimmune regulator). Earlier, we published a case report of type 1 APS in a patient of 8 years old. Now she is 10 years. 1.5 years after the illness of this girl, a similar diagnosis was made to her twin sister. We believe that information about the characteristics of the disease in the twin sisters will make a certain contribution to the creatures.
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