Follicular thyroid carcinoma detected in ⁶⁸Ga-PSMA PET/CT imaging. Case report.

Abstract

Introduction: Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein located on the cell membrane, initially discovered in prostate cells, and highly expressed in the cells and metastases of prostate carcinoma. 68Ga-PSMA PET/CT is a molecular imaging technique widely used in the algorithm of this pathology. PSMA expression has been observed in several malignancies, usually incidentally. We report a case of follicular thyroid carcinoma detected in ⁶⁸Ga-PSMA PET/CT. To our knowledge, only 3 cases have been reported in the literature to date. Clinical findings: Patient with a history of prostate cancer adenocarcinoma, who after initial treatment, presented biochemical recurrence. A Ga68-PSMA PET/CT was performed, showing uptake of the radiopharmaceutical in the left thyroid lobe. Interventions: The patient was evaluated by the head and neck specialty, taken to total thyroidectomy plus central dissection. The pathology report confirms a follicular thyroid carcinoma. Conclusion: Ga68-PSMA PET/CT is a molecular image with high diagnostic performance in prostate cancer, however, its uptake in other solid tumors is well established, so attention should be paid to these uptakes, since the the vast majority may be related to another type of primary tumor. This is an example of PSMA uptake in follicular carcinoma of the thyroid.