Abstract
Like other SLRPs, lumican has a molecular weight of ~40 kDa comprised of four major domains: (1) a signal peptide of 16 residues; (2) a negatively charged N-terminal domain containing sulfated tyrosine and disulfide bond(s); (3) tandem leucine-rich repeats (LXXLXLXXNXLSXL)10 mediating binding to other extracellular components, e.g. collagen; (4) a carboxyl terminal domain of 50 amino acids containing two conserved cysteines 32 residues apart.
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