Abstract
KCNQ/M-channels are slowly gating and non-inactivating K+ channels. They are widely expressed in the nervous system and play major roles in regulation of neuronal excitability. Still controversial is the functional role of M-channels in neurotransmitter release. To clarify this issue, we sought to test drugs known to activate or inhibit M-channels for their effects on transmitter release or synaptic transmission, using hippocampal “micro-island” autapses or mass cultures. A possible confounding issue are effects of the drugs on excitatory or inhibitory inotropic receptors.
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