Organic Letters | VOL. 24
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Fluorogenic Protein Labeling by Generation of Fluorescent Quinoliziniums Using [Cp*RhCl2]2

Publication Date Jul 28, 2022

Abstract

Fluorogenic labeling has received considerable attention as a result of the high demand in chemical biology and synthetic biology applications. Herein, we develop a new strategy for fluorescent turn-on ligation targeting alkyne- and quinoline-linked peptides and proteins (λem of 515 nm and up to ΦF of 0.20) using the [Cp*RhCl2]2 catalyst. The good conversion, high flexibility, broad utility, ease of use, and mild reaction conditions are great advantages to extend the rhodium-mediated turn-on fluorogenic bioconjugation for further applications.

Concepts

Chemical Biology Applications Synthetic Biology Applications Fluorogenic Labeling Mild Reaction Conditions Chemical Synthetic Biology High Flexibility Ease Of Use Fluorescent Targeting Demand In Applications Synthetic Applications

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