Abstract
In developed countries, stenosis is the main cause of death. To investigate hemodynamics within different degrees of stenoses, a stenosis model incorporating fluid–structure interaction and microcirculation function is used in this paper. Microcirculation is treated as a seepage outlet boundary condition. Compliant arterial wall is considered. Numerical simulation based on fluid–structure interaction is performed using finite element method. Our results indicate that (i) the increasing degree of stenosis makes the pressure drop increase, and (ii) the wall shear stress and the velocity in the artery zone may be more sensitive than the pressure with the increase of percentage stenosis, and (iii) there are higher wall shear stress and flow velocity in the post-stenosis region of severer stenosis. This work contributes to understand hemodynamics for different degrees of stenoses and it provides detailed information for stenosis and microcirculation function.
Highlights
Arterial stenosis is a localized narrowing of the arterial lumen
We discuss the pressures of a healthy artery and find that the pressure fluctuation range in the artery zone rises gradually, which matches with clinical observations.[27]
This work is further to validate the effects of stenosis severity on hemodynamics
Summary
Arterial stenosis is a localized narrowing of the arterial lumen. It limits blood supply to tissues and significantly affects the development and formation of cardiovascular diseases. In developed countries, it is the main cause of death, which is greatly concerned. Considerable efforts for flow in stenotic arteries have been made in the past decades.[1,2,3,4,5,6,7] Under these efforts, it has been known that arterial stenosis provokes major disruption of the normal flow patterns and flow disturbances contribute to plaque development. It is vital to understand the changes of the flow with the development of stenosis.
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