Abstract
Drug induced toxic epidermal necrolysis and Stevens Johnson syndrome are more commonly associated with medications such as sulfonamides, penicillin, anticonvulsants, oxicam non-steroidal anti-inflammatory drugs, allopurinol and corticosteroids. Isolated instances secondary to drugs outside of the aforementioned classes have also been reported. We report a case of probable toxic epidermal necrolysis induced by fluconazole in a 52 year old woman.
Highlights
Adverse cutaneous reactions to drugs are common occurrences, affecting 2-3% of hospitalized patients [1]
Isolated instances of Toxic Epidermal Necrolysis (TEN) and Stevens Johnson Syndrome (SJS) secondary to drugs that do not belong to the aforementioned classes have been reported
We report a case of fluconazole induced toxic epidermal necrolysis
Summary
Adverse cutaneous reactions to drugs are common occurrences, affecting 2-3% of hospitalized patients [1]. Drug induced Toxic Epidermal Necrolysis (TEN) and Stevens Johnson Syndrome (SJS) are more commonly associated with medications such as sulphonamides, penicillin and other antibiotics, anticonvulsants, oxicam NSAIDS, allopurinol and corticosteroids. A Medline literature search revealed only three previously reported cases of mucocutaneous drug reactions secondary to fluconazole therapy. We report a case of fluconazole induced toxic epidermal necrolysis. Involving the anterior trunk, the rash later spread peripherally to involve the rest of the trunk, upper and lower extremities, face, palms and soles. She developed marked lip and oral blisters. A diagnosis of fluconazole induced toxic epidermal necrolysis (Naranjo score 6) was made based on the clinical picture.
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