Abstract
Recent technological and scientific research has been devoted to the development of rate-controlled drug delivery system to overcome physiological adversities such as unpredictable gastric emptying times and gastric residence time. FDDS are of particular interest of drugs that are locally active and have narrow absorption window in stomach. FDDS offers numerous advantages, specially the drugs having narrow absorption window in GIT, primary absorption in the stomach, Prolonged gastric retention improves bioavailability, reduces drug waste, and improves solubility for drugs that are least soluble in a high pH environment. This review summarizes the design of the FDDS systems, factors that affect floating system, advantages, limitations, evaluation parameters and applications.
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