Abstract
To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of 30 μg/mL. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.
Highlights
Ionizing radiation is any electromagnetic wave or particle capable of producing ions
Exposure of mice to radiation at 8 Gy led to lethal damage, and pretreatment with from Rosa roxburghii Tratt (FRT) increased the survival rate to 80%, compared with 30% in the untreated irradiation group
FRT elevated the number of colony-forming units in spleen (CFU-S) in mice after exposure to a potentially lethal irradiation
Summary
Ionizing radiation is any electromagnetic wave or particle capable of producing ions. In addition to the importance for cancer treatment patients, radioprotectors are needed to protect other potentially exposed populations, such as workers in the nuclear power industry, space travelers or military personnel facing radiological terrorism from ionizing radiation. Because of their potential importance, researchers put efforts into searching for radioprotectors. Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. These results collectively indicate that FRT is an effective radioprotective agent
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