Flavonoids and antiepileptic drugs: a comprehensive review on their neuroprotective potentials

Abstract

Flavonoids have more potent therapeutic efficacy for the treatment of epileptic disorders. Certain flavonoids possess significant synergistic effects and can be taken with particular antiepileptic drugs (AEDs) to reduce the possibility of drug resistance. The combination of herbal and traditional medicines may not only prevent adverse effects but also increase the drug effects in overall comprehensive efficacy. The present study reviewed the potential efficacy of active constituents of selected flavonoids. Furthermore, in recent years, various researches have been attentive to specific flavonoids for their neuroprotective potential in in-vitro and in-vivo models. We have selected some specific flavonoids that have already proven therapeutic potential in animal epileptic models. Certain flavonoids possess significant synergistic effects and can be taken with particular AEDs to reduce the possibility of drug resistance. Some flavonoids are shown to exhibit their neuroprotective effects in Parkinson's disease, Alzheimer's disease, and ischemic stroke, which are the most common examples of neurological disorders. The major outcomes of flavonoids on progressive neurological disorders may be correlated to the regulation of gamma-aminobutyric acid (GABA) receptors. It has been reported that the neuroprotective actions of naringenin in experimental strokes are mediated by a reduction in NF-B-induced neuroinflammation. These discoveries appear to suggest that some flavonoids are more effective than conventional antiepileptic medicines, which have fewer side effects and can be used for the cure of epileptic seizures. Recently, in many research studies, it has been found that plant-derived flavonoids provide synergistic pharmacological action in experimental models of severe epilepsy. Keywords: Flavonoid, Therapeutic efficacy, Traditional medicine, Neuroprotective effect, Alternative therapy.