Abstract
Cilia and flagella are complex macromolecular assemblies composed of microtubules (MTs) and motors producing complex beating patterns vital for physiology. The periodic beating involves immobilized ciliary dynein stepping on arrays of MTs converted to bending of the complex. While the in vivo mechanics involve MT bending, buckling and collective motor activity, in vitro reconstitution of the components could improve our understanding as seen previously when a kinesin driven MT gliding assay was seen to mimic flagella-like beating based on stochastic MT pinnng.
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