Abstract
Fast and specific self-assembly, together with steric rigidity by base stacking, makes DNA uniquely efficient for building supramolecular nanostructures. However, their non-covalent nature makes subsystems of DNA insufficiently robust for use as building blocks for large systems. We have developed a fixation technology and taken the first step towards the modular build-up of complex larger networks. This is demonstrated for a six membered DNA hexagon, each edge one turn of a double helix, which is covalently cross-linked using click chemistry, creating a robust module that can be readily adapted for building larger systems. This hexagonal module constitutes the smallest practical assembly unit of DNA, a system truly fit for molecular nanotechnology.
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