Abstract
ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Jenny Vermeer and Jonathan lent are co-first authors on ‘A lineage-tracing tool to map the fate of hypoxic tumour cells’, published in DMM. Jenny conducted the research described in this article while a postdoctoral researcher in the lab of Ruth Muschel at the University of Oxford, Oxford, UK. She is now a project leader in the lab of Miranda van der Lee at Byondis, Nijmegen, The Netherlands, investigating new targets, particularly in cancer, that will lead to novel treatments. Jonathan is a PhD student in the lab of Marc Vooijs at Maastricht University, Maastricht, The Netherlands, investigating new cancer targets and testing possible new interventions with a focus on tumour hypoxia.
Highlights
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping earlycareer researchers promote themselves alongside their papers
We have created a tool to study the behaviour of cells that have experienced hypoxia in real time, which will be useful in understanding how they contribute to treatment resistance
What are the potential implications of these results for your field of research? JV: The model we developed opens up a great opportunity to study hypoxic cells in more detail and gain knowledge about their fate and response to treatment
Summary
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping earlycareer researchers promote themselves alongside their papers. Jenny conducted the research described in this article while a postdoctoral researcher in the lab of Ruth Muschel at the University of Oxford, Oxford, UK. She is a project leader in the lab of Miranda van der Lee at Byondis, Nijmegen, The Netherlands, investigating new targets, in cancer, that will lead to novel treatments. We visualised hypoxic cells in a mouse tumour with a microscope. This model makes it possible to study hypoxia in great detail and this knowledge can help to improve treatment strategies
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