Abstract
ABSTRACT This report describes the first Brazilian equine herpesvirus type 1 (EHV-1) isolation from a single fatal equine herpes myeloencephalopathy case in a mare. The isolation of EHV-1 was confirmed from the first passage of cerebrospinal fluid (CSF) sample in Vero cells by PCR and virus neutralization assay. As virus isolation from CSF is unlikely to be successful, as has been shown in several case reports, this circumstantial evidence suggests that the neurological disease was caused by particularly neurovirulent strain of EHV-1.
Highlights
PRIMEIRO ISOLAMENTO NO BRASIL DE HERPESVIRUS EQÜINO TIPO 1 EM UM CAVALO COM DOENÇA NEUROLÓGICA
Equine herpesvirus type 1 (EHV-1) is ubiquitous in the horse populations, there has been no report of confirmed virus isolation or detection from nervous tissue or cerebrospinal fluid (CSF) of equine neurological cases in Brazil ( CARVALHO et al, 2000; GOEHRING et al, 2006)
A definitive diagnosis of equine herpes myeloencephalopathy (EHM) can only be supported by the following laboratory tests: 1) EHV-1 isolation from CSF or brain tissue; 2) identification of viral particles, inclusions, antigen, or nucleic acid in central nervous system (CNS) tissue (REED; TORIBIO, 2004; DAVIS; TYLER, 2005)
Summary
PRIMEIRO ISOLAMENTO NO BRASIL DE HERPESVIRUS EQÜINO TIPO 1 EM UM CAVALO COM DOENÇA NEUROLÓGICA. EHV-1 is ubiquitous in the horse populations, there has been no report of confirmed virus isolation or detection from nervous tissue or cerebrospinal fluid (CSF) of equine neurological cases in Brazil ( CARVALHO et al, 2000; GOEHRING et al, 2006). In concordance with the pathophysiology of the disease, attempts to isolate the virus from the CSF or CNS tissue are seldom successful (PELLEGRINI-MASINI; LIVESEY, 2006).
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