Abstract
AbstractHerein we present the first catalytic enantioselective Wittig reaction. Chiral mono‐ and diphosphines were employed as catalysts for the desymmetrization of a prochiral ketone. The reaction was performed under microwave dielectric heating as well as under conventional heating. Selected catalysts led to moderate to good yields and enantioselectivities. In the presence of (+)‐1,2‐bis[(2S,5S)‐2,5‐dimethylphospholano]benzene [(S,S)‐Me‐DuPhos], an enantiomeric excess of up to 90 % was obtained.
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