Abstract
Living in close proximity to the sediment of coastal areas, bivalves may be exposed to veterinary antibiotic residuals and microplastics (MPs) simultaneously. However, the immunotoxic impacts of veterinary antibiotics remain unknown in bivalves, let alone their interactions with MPs. Therefore, the immune responses of two representative veterinary antibiotics, oxytetracycline and florfenicol, was investigated in a bivalve species, the blood clam (Tegillarca granosa). The effects of the copresence of MPs on the immune responses triggered by these antibiotics were also analyzed. Results showed that exposure to antibiotics investigated led to significant alteration in hematic parameters and reduction in lectin content in serum. In addition to inducing ROS production, aggravating lipid peroxidation and DNA damage, and suppressing the hemocyte viability, antibiotic treatments also downregulated the expression of immune- and detoxification-related genes but upregulated apoptosis-related Caspase-3. Furthermore, the toxic impacts of antibiotics were found to be significantly increased by the copresence of MPs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
