Abstract
Filtration patterns from the pulmonary vascular bed into the pleural space differ from those for the airway spaces. In the pleural space, the direction and the rate of filtration are proportional to the vascular-pleural pressure differences. Filtration into the airway is inhibited as long as vascular pressure exceeds airway pressure by less than 12cm. H2O. At higher transmural pressures filtration is very rapid. Retrograde perfusion produces more filtration than antegrade perfusion. These data suggest that the transmural filtration occurs at the venous end of the capillaries and perhaps in the venules. A special property of the airway prevents filtration until a critical value is achieved. The significance of these filtration patterns in ventilation, effusion and edema are discussed.
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