Abstract
The filterability of density-separated fractions of red blood cells (RBC), neutrophils and mononuclear cells was evaluated to determine their relative contribution to resistance to blood flow. Increasing RBC density was associated with smaller cell size, greater haemoglobin concentration, and improved filterability. Filtration of RBC, after adrenaline-induced splenic contraction, failed to identify a population of non-deformable RBC. Leucocytes filtered less readily compared to RBC. Neutrophils and mononuclear cells produced similar initial pressure increments but mononuclear cells had a greater potential to plug pores in the filters. Our results indicate both RBC and leucocytes may contribute to resistance to blood flow. A subpopulation of non-deformable RBC could not be identified in circulating blood or in blood after adrenaline-induced splenic contraction.
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