Abstract

<p>Monitoring changes in GR signaling in patients with localized hormone naïve disease treated with ADT. <b>A,</b> Preoperative trial NCT03279250 Clinical data and PSA concentration at BL and after 6 months of treatments (6 months). <b>B,</b> PSA and steroid levels in plasma, PSA (****, <i>P</i> <0.0001), testosterone (****, <i>P</i> <0.0001). <b>C,</b> Steroid levels in plasma cortisol (**, <i>P</i> = 0.0045). <b>D,</b> GR expression in RNA from EVs transcriptome analysis at BL and after 6 months of treatment. Patients were divided in two different groups bases on upregulation >0.5 or downregulation <0.5 of GR expression. Differential GR expression in GR− and GR+ groups from transcriptome analysis in plasma-derived EVs: GR+ (*, <i>P</i> = 0.0125). <b>E,</b> GR expression in tissues collected from patient's prostatectomy after therapy. IHC images from selected patients GR− and GR+ and IHC quantification of all GR+ and GR− patients with ImageJ.</p>

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