Abstract
Human T-cell leukemia virus type 1 was isolated as the retrovirus to be identified in humans. Here, we focused on Ficus pumila L. as a factor that be effective against human T-cell leukemia virus type 1. The significant and novel findings is that symptoms of patients with drinking Ficus pumila L. extracts did not worsen despite a lack of aggressive pharmacotherapy against adult T-cell leukemia, a human T-cell leukemia virus type 1-associated myelopathy, or T-cell leukemia virus type 1 uveitis. Twenty-eight of the 194 inpatients who underwent showed high levels of human T-cell leukemia virus type 1.Among human T-cell leukemia virus type 1-infected patients, those who were administered Ficus pumila L. extracts had no human T-cell leukemia virus type 1-related symptoms, while those who were not administered Ficus pumila L. extracts had human T-cell leukemia virus type 1-related diseases and a significantly poorer prognosis. This suggests that the Ficus pumila L. extracts may show some utility against virus infection.
Highlights
Human T-cell leukemia virus type 1 (HTLV-1) has been isolated from humans
HTLV-1 was first isolated and described by Montagnier and Gallo, and is the first pathogenic retrovirus to be identified in humans
Since coronavirus is a single-stranded, plus strand RNA virus and the genome itself acts as mRNA, it is presumed that up-down regulation by miRNA in the early stage of infection is effective for therapeutic miRNA
Summary
Human T-cell leukemia virus type 1 (HTLV-1) has been isolated from humans. HTLV-1 is a type C retrovirus that is primarily endemic to Japan, Central and South America, the Middle East, regions of Africa, and the Caribbean. Main text Human T-cell leukemia virus type 1 (HTLV-1) has been isolated from humans. HTLV-1 and related diseases are common in southwestern Japan, especially in rural areas of Kyushu and Okinawa, and Japan is the only developed nation that is an HTLV-1-endemic country.
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