Abstract
BackgroundMatrix metalloproteinases (MMPs) and C-reactive protein (CRP) are involved in chronic obstructive pulmonary disease (COPD) pathogenesis. The aim of the present work was to determine plasma concentrations of MMPs and CRP in COPD associated to biomass combustion exposure (BE) and tobacco smoking (TS).MethodsPulmonary function tests, plasma levels of MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and CRP were measured in COPD associated to BE (n = 40) and TS (n =40) patients, and healthy non-smoking (NS) healthy women (controls, n = 40).ResultsPlasma levels of MMP-1, MMP-7, MMP-9, and MMP-9/TIMP-1 and CRP were higher in BE and TS than in the NS healthy women (p <0.01). An inverse correlation between MMP-1, MMP-7, MMP-9, MMP-9/TIMP-1 and CRP plasma concentrations and FEV1 was observed.ConclusionsIncrease of MMPs and CRP plasma concentrations in BE suggests a systemic inflammatory phenomenon similar to that observed in COPD associated to tobacco smoking, which may also play a role in COPD pathogenesis.
Highlights
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity worldwide [1]
Pulmonary function tests Both Forced expiratory volume in the 1st second (FEV1) (% predicted) and Forced vital capacity (FVC) (% predicted) were significantly lower in women with chronic obstructive pulmonary disease (COPD) associated to smoking in comparison to control healthy women and Control n = 40
The main findings of this work are that: 1) metalloproteinases 1, 7, and 9, the Matrix metalloproteinase-9 (MMP-9)/TIPM-1 ratio and C-reactive protein (CRP) concentrations are increased in plasma of subjects with COPD associated to biomass combustion exposure (BE), and: 2) an association among these increases and FEV1 exists
Summary
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and morbidity worldwide [1]. Tobacco smoking is well recognized as the major risk factor for the disease, exposure to biomass smoke (BE) and other fuel combustion products has been described as an additional risk factor [2,3]. Elevated circulating levels of C-reactive protein (CRP) among other inflammatory markers [7], such as plasma and sputum matrix metalloproteinases (MMPs) and the tissue inhibitor of metalloproteinase-(TIMP)-1 levels have been reported, suggesting their participation in the pathogenesis of COPD secondary to TS [8,9,10,11]. Matrix metalloproteinases (MMPs) and C-reactive protein (CRP) are involved in chronic obstructive pulmonary disease (COPD) pathogenesis. The aim of the present work was to determine plasma concentrations of MMPs and CRP in COPD associated to biomass combustion exposure (BE) and tobacco smoking (TS)
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