Abstract
We report a case of fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21. A stillborn baby, delivered at 15 weeks and 5 days of gestation, had a huge nuchal cystic hygroma. Autopsy revealed aortic coarctation of the periductal type with patent ductus arteriosus, endocardial cushion defect and left ventricular hypoplasia. Trisomy 21 was evident by karyotyping. Macroscopically, while an apparent association of nuchal cystic hygroma and aortic coarctation resembled Turner syndrome, histopathological findings were those typically seen in trisomy 21: numerous dilated lymphatics in the subcutaneous tissue with severe mesenchymal edema, and an enlarged jugular lymphatic sac.
Highlights
Various lymphatic abnormalities cause jugular lymphatic distension resulting in nuchal edema and cystic hygroma [1,2]
We report a case of fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21
While an apparent association of nuchal cystic hygroma and aortic coarctation suggested the presence of Turner syndrome, histopathological findings were those typically seen in trisomy 21
Summary
Various lymphatic abnormalities cause jugular lymphatic distension resulting in nuchal edema and cystic hygroma [1,2]. Abstract We report a case of fetal nuchal cystic hygroma associated with aortic coarctation and trisomy 21. A stillborn baby, delivered at 15 weeks and 5 days of gestation, had a huge nuchal cystic hygroma.
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