Feeding Chicks High Levels of l-Phenylalanine and l-Methionine Supplemented Diets in the Study of Experimental Aspects of Phenylketonuria and Homocystinuria

Abstract

WITH the increased number of biochemical anomalies associated with mental deficiency in man, i.e. phenylketonuria, homocystinuria, hyperglycemia and with the discoveries that some of the “inborn errors of metabolism” are partially susceptible to nutritional manipulation, there is increased interest in employing various animal species in the study of phenylketonuria (PKU). PKU studies have been conducted with the rat (Auerbach et al., 1958; Huang et al., 1961; Yuwiler and Loutit, 1961; Goldstein, 1961; Wang and Waisman, 1961; Guroff and Udenfriend, 1962; Green et al., 1962; Boggs and Waisman, 1962; Culley et al, 1962; Boggs et al., 1963; Quay, 1963; Boggs and Waisman, 1964; Freedland et al., 1964; Woods and McCormick, 1964; and Yuwiler et al., 1965), the mouse (Wooley and van der Hoeven, 1963, 1964), the rabbit (Ammon, 1961), the monkey (Waisman et al., 1959, 1960; Waisman, 1962) and the dog (Himwich et al., 1965). To the author’s best knowledge the …