Abstract
In response to genome stresses, cell can trigger the self-defensive mechanisms by regulating the vital genes and their complicated signal pathways. To illustrate the celluar response in fighting against DNA damage under radiotherapy, a feedback-control model of P53 stress response networks is proposed at single cell level. The kinetics of Double Strand Breaks(DSBs) generation and repair, ARF and ATM activation, P53-MDM2 regulation, toxins degradation, as well as feedback-control to ion radiation (IR) dose are presented.
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