Abstract
Heterogeneity by types of genodermatoses inheritance from the group of ichthyosis, which include virtually all possible variants, is the basis for the application of one of the genetic methods of human study - the method of dermatoglyphics. The purpose of the study is to determine the peculiarities of the quantitative indexes of finger and palmar dermatoglyphics in men and women with ichthyosis. Dermatological examination was performed in 49 patients with ichthyosis and 136 dermatologically healthy persons. The sample of patients was conducted randomly. All persons received informed consent for conducting observations. Fingerprint and palm prints are obtained by scanning fingerprints on paper by the Futronic's FS8 USB2.0 Fingerprint Scanner using the ftrScanApiEx.exe program, and then transferring data to a personal computer. Processing of dermatoglyphics data was carried out according to the method of Cummins H. and Midlo Ch. (1961). The quantitative indices of both finger and palmar dermatoglifics were determined. The calculation of the received results was carried out in the licensed software package “Statistica 5.5”. The average sample values (M) and dispersion (σ) were determined in the groups of the subjects surveyed. Using the Mann-Whitney U-test determined the probability of differences in the results obtained for individual groups. A certain complex of quantitative signs of palmar dermatoglyphics is revealed, which is characteristic for men suffering from ichthyosis, which includes indexes of the intensity of the comb formations, the value of the length of the segment c-t, the value of the palm corners and the Cummins index. In women suffering from ichthyosis, such a complex includes, as in men, indicators of the intensity of the combs and the length of the segment c-t, except for which - also the value of palm comb accounts. Given the specific lamellar form of ichthyosis, the dermatoglyphic picture (monomorphism of established signs on both hands: the presence of a single 4-finger flexural fold, a pattern in the III interdigital gap, low localization of the carpal angle atd, and the presence of the ulnar loop, complicated by the internal pattern on the III finger of the left and the IV the finger of the right hand brushes), the authors concluded that the study of ichthyosis should be carried out necessarily for each form of ichthyosis separately, which significantly increases the resolution of the method of dermatoglyphics.
Highlights
At the heart of the scientific interest of geneticists, clinicians and anthropologists in dermatoglyphics is the understanding of the high hereditary condition of the skin pattern and the possibility of using it as a marker of hereditary diseases [28, 31, 32, 33], and the morphogenetic marker [1, 9, 16, 20, 21, 22, 33]
Men suffering from ichthyosis have a significantly lower finger comb score of I (17.41 ± 5.72 vs. 19.94 ± 6.16 comb, p
There was no difference between the sick and healthy women according to these indicators
Summary
At the heart of the scientific interest of geneticists, clinicians and anthropologists in dermatoglyphics is the understanding of the high hereditary condition of the skin pattern and the possibility of using it as a marker of hereditary diseases [28, 31, 32, 33], and the morphogenetic marker [1, 9, 16, 20, 21, 22, 33]. The results of which formed the understanding of the association of signs of dermatoglyphics with a number of diseases of multifactorial nature [8, 10,11,12,13,14, 17, 24, 26, 29, 30], where dermatoglyphics plays, as a rule, a prognostic role. Ichthyosis encompasses a heterogeneous group of hereditary skin diseases that can be congenital or develop in childhood [5]. Given that genodermatosis from the group of ichthyosis are heterogeneous by types of inheritance.
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