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Abstract
Objective. To evaluate the features of manifestations of active Epstein–Barr virus (EBV) infection in children and to clarify the possibilities of etiotropic therapy. Patients and methods. Seventy children aged 3 to 7 years were included in the study. The main group included 35 children with laboratory signs of EBV activity, the comparison group included 35 children with negative results. The results of different approaches to therapy were evaluated in the main group. Results. Lymphadenopathy (71%), hyperemia of the posterior pharyngeal wall (100%), enlargement of tonsils (74%), plaques on tonsils (51%), enanthema (46%) were more frequently registered against the background of EBV infection. The duration of catarrhal symptoms, lymphadenopathy, and the duration of the acute period were longer than 24 hours. In children treated with inosine pranobex, the main manifestations of EBV infection were reliably faster, more than a day, and there were no cases of new symptoms and complications. Conclusion. Children with active EBV infection are characterized by lymphadenopathy, hyperemia of the posterior pharyngeal wall, enlargement of tonsils, plaques on tonsils (sometimes in combination with plaques of other localization), enanthema. Children with active EBV infection have a longer duration of episodes of acute respiratory symptoms, 4.5 times higher incidence of incomplete recovery. Inosin pranobex reduces the duration of acute respiratory symptoms in active EBV infection and prevents the development of complications. Key words: herpes virus type 4, Epstein–Barr virus, herpesvirus infection, inosine pranobex, infectious mononucleosis, ARVI
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