Feature and utility in diagnosis of papillary thyroid carcinoma by immunohistochemistry CD56

Abstract

Diagnosis of papillary thyroid carcinoma (PTC), is easily accessible diagnosis with less interobservable by experts and scientist but, some cases of PTC, such as the follicular variant, is consider as a big challenge and exhibits interobservable variability for expert pathologists. therefore, the suitable diagnosis and characterization of papillary thyroid carcinoma is important due to is play a role in clinical management arrangements, and give clear indications that papillary thyroid carcinoma must be clear enough to be an objective diagnosis. But, up to the date immunohistochemistry and molecular studies have not given the desired attention to overcome this problem. This study done to overcome this problem, a total number of study patients was 50. They were divided into three groups, papillary group included 30 patients diagnosed as papillary thyroid carcinoma, follicular group included 15 patients diagnosed as follicular thyroid carcinoma, and hyperplasia group included five patients diagnosed as thyroid hyperplasia. The study reach to CD56 marker sensitivity is 100%, specificity is 90%, and accuracy of CD56 marker to diagnose papillary thyroid carcinoma was 96%. predictive (+) value was 93.8%, while predictive (-) value was 100%.