Abstract
11583 Background: Breast-conserving surgery (BCS) is a standard care for early breast cancer patients. However, local control is not sufficient for surgery alone and breast irradiation and hormonal treatment in hormone-sensitive tumor should be recommended to reduce 10% or less of local failure rate. To evaluate the safety and reliability of thermal ablation therapy instead of BCS, we performed radiofrequency ablation therapy (RFA) for stage I breast cancer patients. Methods: Thirty female breast cancer patients with no extensive intraductal spread were enrolled. Under general anesthesia, sentinel node biopsy, and then RFA immediately followed by BCS was performed. Resected specimens were examined at 5 mm intervals by hematoxylin-eosin (HE) staining and several slices of tumor and non tumor lesions in each case were also evaluated by nicotinamide adenine dinucleotide (NADH) diaphorase staining. Results: Tumor diameters with breast ultrasound ranged from 0.9 cm to 2.4 cm. RFA-relating adverse events were o...
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