Abstract
To evaluate the feasibility and safety of endoscopic closure of esophageal perforation with an over-the-scope clip (OTSC) system in a surviving canine model. Esophageal perforations (20-mm diameter) were created by an endoscopic needle-knife in 10 dogs. Then the perforations were closed by the OTSC system. And gastroscopy was performed weekly to evaluate the postoperative perforation healing. Esophageal perforations could primarily be closed with one OTSC in each experimental dog. The mean handling time was 24 (18-33) min. All animals survived without postoperative complications. The retention of OTSC was observed in all dogs at the end of 3 weeks. The OTSC system can reliably close esophageal perforations without complications.
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