Abstract
To show the feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging in terms of its capability to provide new contrast information of abscess lesion and characterize time-course variations before and after the induction of brain abscess. Brain abscess was induced in healthy beagles by a direct inoculation method using Staphylococcus pseudintermedius. After the induction, four electrodes were attached on the head and the dog was placed inside the magnetic resonance imaging (MRI) bore. Using a current source, we injected a current of amplitude 5 mA and a pulse width of 81 msec. A multi-echo ICNE pulse sequence was used to obtain the magnetic flux density (Bz ) data. The relative conductivity contrast ratios (rCCR, %) of abscess lesion were significantly changed by the postinduction time (P < 0.01). The rCCRs of central abscess lesions were higher than the surrounding area at 6, 12, and 18 hours (P < 0.01). Over 12 hours, the relationship between the induction time and rCCR showed a positive correlation followed by a negative correlation (P < 0.01). We performed in vivo disease model animal experiments to validate the MREIT technique providing conductivity information of tissues in situ to be utilized in clinical applications.
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