Abstract
Background: The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been used extensively in various products since the 1980s. Recently, a biocide containing only MI and not MCI has been launched on the Swedish market for use in industrial settings, paints and glues.Objectives: To describe sensitization to the unchlorinated isothiazolinone 2‐methyl‐4‐isothiazolin‐3‐one (MI) in 2 workers, a technician after a chemical burn and a painter, both exposed to a preservative containing MI. Methods: Patch testing with serial dilutions of MCI/MI, MCI, MI, 2‐n‐octyl‐4‐isothiazolin‐3‐one (OIT) and a commercial preservative containing MI in the 2 workers.Results: The patients reacted positively to MCI/MI and to the separate active ingredients (MCI, MI). The patch test reactivity to MI was higher than the reactivity to MCI, which is a reversed pattern to what is usually seen in patients sensitized to MCI/MI. Both patients also had positive test reactions to OIT.Conclusion: MI may sensitize on it’s own, and in patients allergic to MI, cross‐reactions are also seen to MCI.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
